Cysteinyl leukotriene induces eosinophil extracellular trap formation via cysteinyl leukotriene 1 receptor in a murine model of asthma.

Aline Andrea da Cunha Josiane Silva Silveira Géssica Luana Antunes Keila Abreu da Silveira Rodrigo Benedetti Gassen Ricardo Vaz Breda Paulo Márcio Pitrez

Published in: Experimental lung research (2021)

We revealed that the decrease in cysLT production or cysLT1 receptor inhibition by MK-886 or/and MK-571 treatments, respectively reduced EET formation in BALF, showing that cysLT regulates the activation process of EET release in asthma.

Keyphrases

chronic obstructive pulmonary disease
lung function
single cell
cystic fibrosis
air pollution