The Potential of Secondary Metabolites from Plants as Drugs or Leads against Trypanosoma cruzi -An Update from 2012 to 2021.
Henrique BarbosaFernanda ThevenardJuliana Quero ReimãoAndre Gustavo TemponeKathia Maria HonorioJoao Henrique Ghilardi LagoPublished in: Current topics in medicinal chemistry (2023)
In this aspect, there are several compounds with high potential which could be considered as a scaffold for the development of new drugs for the treatment of Chagas disease-for this, more advanced studies must be performed including pharmacokinetics (PK) and pharmacodynamics (PD) analysis as well as conduction of in vivo assays, these being important limitations in the discovery of new anti-T. cruzi compounds.