Oral cancer stem cells drive tumourigenesis through activation of stromal fibroblasts.

Mohanad Jameel Najm Al-Magsoosi Daniel W Lambert Syed Ali Khurram Simon A Whawell

Published in: Oral diseases (2020)

Adherence to fibronectin and chemoresistance isolates stem-like cells that can activate fibroblasts, which together with a correlation between markers of both in vivo, provides a mechanism by which such cells drive tumourigenesis.

Keyphrases

stem cells
induced apoptosis
extracellular matrix
cell cycle arrest
bone marrow
oxidative stress
cell therapy
type diabetes
cell death
metabolic syndrome
adipose tissue
weight loss