Sex bias in celiac disease: XWAS and monocyte eQTLs in women identify TMEM187 as a functional candidate gene.
Alba Hernangomez-LaderasAriadna Cilleros-PortetSilvia Martínez VelascoSergi MaríMaría LegardaBárbara Paola González-GarcíaCarlos TutauIraia García-SantistebanIñaki IrastorzaNora Fernandez-JimenezJose Ramon BilbaoPublished in: Biology of sex differences (2023)
Using X chromosome genotypes and gene expression data from female monocytes, SMR has identified TMEM187 as a potentially causal candidate in CeD. Further studies are needed to understand the implication of the X chromosome in the higher prevalence of CeD in women.
Keyphrases
- celiac disease
- gene expression
- copy number
- polycystic ovary syndrome
- dendritic cells
- pregnancy outcomes
- dna methylation
- peripheral blood
- risk factors
- cervical cancer screening
- genome wide
- breast cancer risk
- big data
- pregnant women
- type diabetes
- insulin resistance
- machine learning
- metabolic syndrome
- adipose tissue
- case control
- data analysis