A novel substrate for arrhythmias in Chagas disease.
Artur Santos-MirandaJulliane V Joviano-SantosJaqueline O SarmentoAlexandre D CostaAllysson T C SoaresFabiana S MachadoJader Dos Santos CruzDanilo Roman CamposPublished in: PLoS neglected tropical diseases (2021)
The present study is the first to describe NCX as a cellular arrhythmogenic substrate in chagasic cardiomyocytes. Our data suggest that NCX could be relevant to further understanding of arrhythmogenesis in the chronic phase of experimental CD and blocking NCX may be a new therapeutic strategy to treat arrhythmias in this condition.