Modeling PNPLA3-Associated NAFLD Using Human-Induced Pluripotent Stem Cells.
Samantha G TilsonCarola M MorellAn-Sofie LenaertsSeung Bum ParkZongyi HuBenjamin JenkinsAlbert KoulmanTsanyang Jake LiangLudovic VallierPublished in: Hepatology (Baltimore, Md.) (2021)
Together, these results indicate that the I148M variant induces a loss of function predisposing to steatosis and increased susceptibility to hepatotoxins.