Anti-inflammatory effects of infliximab and methotrexate on peripheral blood and synovial fluid mononuclear cells: ex vivo study.

Smadar GertelM RokachAri PolachekI LitinskyM AnoukOri Elkayam Victoria Furer

Published in: Scandinavian journal of rheumatology (2024)

Both IFX and MTX effectively inhibited PBMC proliferation and IFN-γ production, but only IFX reduced synovial monocytes and pro-inflammatory gene expression in SFMCs, suggesting a differential impact of IFX and MTX on critical inflammatory cell populations ex vivo.

Keyphrases

peripheral blood
gene expression
induced apoptosis
dendritic cells
signaling pathway
cell cycle arrest
single cell
oxidative stress
dna methylation
high dose
cell therapy
cell death
ulcerative colitis
cell proliferation