N-Acetyl Cysteine Treatment Restores Early Phase Fracture Healing in Ethanol-Fed Rats.
Michael J DuryeeAnand DusadCarlos D HunterKusum K KharbandaJoseph D BruenjesKaren C EasterlingJustin C SieblerGeoffrey M ThieleDennis A ChakkalakalPublished in: Alcoholism, clinical and experimental research (2018)
Oxidative stress and excessive inflammation are involved in the inhibition of fracture healing by EtOH. In this study, early short-term treatment of EtOH-fed animals with the antioxidant NAC reduced oxidative stress and normalized the innate immune response to fracture in the early phase of fracture healing, thereby restoring the normal onset of bone regeneration.