Integrated Pharmacokinetics/Pharmacodynamics Model and Simulation of the Ticagrelor Effect on Patients with Acute Coronary Syndrome.
Zhiyan LiuYaou LiuGuangyan MuHanxu ZhangShuang ZhouZhe WangQiufen XieZining WangNinghong GuoJie HuangLiping GuoYan HuangJian LiGuoping YangDongdong YuanHongtao SongJie JiangQian XiangYi Min CuiPublished in: Clinical pharmacokinetics (2023)
A fixed dose of ticagrelor, without adjusting the dosing regimen other than covariates of FOOD/WT/SEX, could be used in patients with acute coronary syndromes, and the standard regimen could be used in Chinese patients from the perspective of exposure.