The role of serotonin in the control of esophageal sensitivity assessed by multimodal stimulation in health.
Charlotte BroersAnnelies GeeraertsVeerle BoecxstaensBrecht Van HoutteHannelore GeysenNele PeersmanPieter VermeerschTim VanuytselTack JanAns PauwelsPublished in: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society (2020)
ATD, which induces 5-HT depletion, significantly decreased pain perception threshold during chemical stimulation, without affecting sensitivity to mechanical, thermal, or electrical stimulation. These findings confirm the involvement of 5-HT in the control of esophageal acid sensitivity, but identifying the receptors involved requires more ligands and studies.