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The role of serotonin in the control of esophageal sensitivity assessed by multimodal stimulation in health.

Charlotte BroersAnnelies GeeraertsVeerle BoecxstaensBrecht Van HoutteHannelore GeysenNele PeersmanPieter VermeerschTim VanuytselTack JanAns Pauwels
Published in: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society (2020)
ATD, which induces 5-HT depletion, significantly decreased pain perception threshold during chemical stimulation, without affecting sensitivity to mechanical, thermal, or electrical stimulation. These findings confirm the involvement of 5-HT in the control of esophageal acid sensitivity, but identifying the receptors involved requires more ligands and studies.
Keyphrases
  • healthcare
  • chronic pain
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  • spinal cord injury
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  • neuropathic pain
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  • risk assessment
  • spinal cord
  • climate change