Relationship of microvascular density on histological and immunohistochemical features in endometrioid adenocarcinomas of the uterus: experimental study.
Mykola LyndinOlga KravtsovaKateryna SikoraYulia LуndіnaYana SikoraWireko Andrew AwuahMohammad M HasanToufik Abdul-RahmanVladyslav SikoraNataliia HyriavenkoAnatolii RomaniukPublished in: Annals of medicine and surgery (2012) (2023)
EA progression is accompanied by qualitative and quantitative variations of parenchymal and stromal patterns of tumors. Dedifferentiation of EA leads to overexpression of VEGF, which becomes diffuse in tumors cells, resulting in an increase of adenocarcinomas' MVD and their metastatic potential. Correlations between histological and immunohistochemical features of EAs indicate the synchronicity of the occurrence and progression of morphological and immunological anaplasia, which can be used in predicting the course of the disease.
Keyphrases
- induced apoptosis
- squamous cell carcinoma
- cell cycle arrest
- small cell lung cancer
- risk assessment
- cell proliferation
- bone marrow
- endothelial cells
- vascular endothelial growth factor
- endometrial cancer
- systematic review
- high resolution
- low grade
- squamous cell
- transcription factor
- endoplasmic reticulum stress
- human health
- cell death