Toxic Metal and Essential Element Concentrations in the Blood and Tissues of Pancreatic Ductal Adenocarcinoma Patients.
Giovanni ForteAndrea PisanoBeatrice BoccaGrazia FenuCristiano FaraceFederica EtziTeresa PerraAngela SabalicAlberto PorcuRoberto MadedduPublished in: Toxics (2024)
This study revealed evidence of altered metal levels in the blood and pancreatic tissues of PDAC patients with respect to healthy controls. These changes may contribute to multiple mechanisms involved in metal-induced carcinogenesis, including oxidative stress, DNA damage, genetic alteration, decreased antioxidant barriers and inflammatory responses. Thus, the analysis of metals can be used in the diagnosis and monitoring of PDAC neoplasms.
Keyphrases
- oxidative stress
- dna damage
- diabetic rats
- end stage renal disease
- gene expression
- chronic kidney disease
- ejection fraction
- newly diagnosed
- prognostic factors
- peritoneal dialysis
- ischemia reperfusion injury
- dna repair
- single cell
- genome wide
- copy number
- anti inflammatory
- dna methylation
- patient reported outcomes
- heavy metals
- drug induced
- human health
- health risk assessment
- endoplasmic reticulum stress
- patient reported