Impaired neuromuscular function by conjoint actions of organophosphorus insecticide metabolites omethoate and cyclohexanol with implications for treatment of respiratory failure.
Kosala N DissanayakeRobert Chang-Chih ChouAdrian ThompsonFilip MargetinyCharlotte DavieScott McKinnonVishwendra PatelLester SultatosJoseph J McArdleRichard E CluttonMichael EddlestonRichard R RibchesterPublished in: Clinical toxicology (Philadelphia, Pa.) (2021)
The data indicate a crucial role for organophosphorus and solvent metabolites in muscle weakness following ingestion of agricultural OP insecticide formulations. The metabolites omethoate and cyclohexanol acted conjointly to impair neuromuscular function but their effects were mitigated by elevating extracellular Mg2+ and decreasing core temperature, respectively. Clinical studies of MgSO4 therapy and targeted temperature management in insecticide-poisoned patients are required to determine whether they may be effective adjuncts to treatment.
Keyphrases
- ms ms
- respiratory failure
- end stage renal disease
- aedes aegypti
- ejection fraction
- extracorporeal membrane oxygenation
- chronic kidney disease
- peritoneal dialysis
- electronic health record
- heavy metals
- stem cells
- intensive care unit
- mesenchymal stem cells
- cancer therapy
- combination therapy
- artificial intelligence
- data analysis
- solar cells
- myasthenia gravis