Research Advances on Stem Cell-Derived Extracellular Vesicles Promoting the Reconstruction of Alveolar Bone through RANKL/RANK/OPG Pathway.
Xia HuangYuxiao LiHui LiaoXin LuoYueping ZhaoYadong HuangZhiying ZhouQi XiangPublished in: Journal of functional biomaterials (2023)
Periodontal bone tissue defects and bone shortages are the most familiar and troublesome clinical problems in the oral cavity. Stem cell-derived extracellular vesicles (SC-EVs) have biological properties similar to their sources, and they could be a promising acellular therapy to assist with periodontal osteogenesis. In the course of alveolar bone remodeling, the RANKL/RANK/OPG signaling pathway is an important pathway involved in bone metabolism. This article summarizes the experimental studies of SC-EVs applied for the therapy of periodontal osteogenesis recently and explores the role of the RANKL/RANK/OPG pathway in their mechanism of action. Their unique patterns will open a new field of vision for people, and they will help to advance a possible future clinical treatment.
Keyphrases
- bone loss
- bone mineral density
- bone regeneration
- stem cells
- soft tissue
- signaling pathway
- postmenopausal women
- nuclear factor
- mental health
- bone marrow
- immune response
- minimally invasive
- drinking water
- toll like receptor
- epithelial mesenchymal transition
- mesenchymal stem cells
- endoplasmic reticulum stress
- case control
- pi k akt