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De novo emergence, existence, and demise of a protein-coding gene in murids.

Jan PetrzilekJosef PasulkaRadek MalikFilip HorvatShubhangini KatarukaHelena FulkaPetr Svoboda
Published in: BMC biology (2022)
While this evolving gene is not showing a clear function in laboratory mice, its documented evolutionary history in Muroidea during the last ~ 40 million years provides a textbook example of how a several common mutation events can support de novo gene formation, evolution of protein-coding capacity, as well as gene's demise.
Keyphrases
  • genome wide
  • copy number
  • genome wide identification
  • dna methylation
  • gene expression
  • insulin resistance
  • high fat diet induced
  • wild type