Network Pharmacology and Molecular Docking Analysis on Mechanisms of Scutellariae Radix in the Treatment of Cerebral Ischemia-reperfusion Injury.

Yang Yang Mengrong Xu Wenting Yuan Yue Feng Yongqiang HouFei FangShiwan DuanLu Bai

Published in: Combinatorial chemistry & high throughput screening (2023)

The active compound of SR was able to significantly decrease the apoptosis of HT22 cells induced by OGD/R. This finding suggests that SR is a potentially effective treatment for CI/R by modulating the MAPK and PI3K-Akt pathways.

Keyphrases

cell cycle arrest
pi k akt
signaling pathway
molecular docking
oxidative stress
ischemia reperfusion injury
induced apoptosis
cell death
cell proliferation
molecular dynamics simulations
endoplasmic reticulum stress
subarachnoid hemorrhage
smoking cessation
cerebral ischemia