Mitigation of MAFLD in High Fat-High Sucrose-Fructose Fed Mice by a Combination of Genistein Consumption and Exercise Training.
Chaheyla R St AubinAmy L FisherJose A HernandezTom L BroderickLayla Al-NakkashPublished in: Diabetes, metabolic syndrome and obesity : targets and therapy (2022)
Our results indicate that a HFHS diet is obesogenic, inducing metabolic perturbations consistent with T2DM and MAFLD. Genistein alone and genistein combined with moderate intensity exercise were effective in reducing MAFLD and the aberrations induced by chronic HFHS feeding.