LncRNA PVT1 promotes gemcitabine resistance of pancreatic cancer via activating Wnt/β-catenin and autophagy pathway through modulating the miR-619-5p/Pygo2 and miR-619-5p/ATG14 axes.
Cefan ZhouChanghua YiYongxiang YiWenying QinYanan YanXueying DongXuewen ZhangYuan HuangRui ZhangJie WeiDeclan William AliMarek MichalakXing-Zhen ChenJingfeng TangPublished in: Molecular cancer (2020)
These data indicate that PVT1 plays a critical role in the sensitivity of pancreatic cancer to gemcitabine and highlight its potential as a valuable target for pancreatic cancer therapy.
Keyphrases
- cancer therapy
- signaling pathway
- cell proliferation
- epithelial mesenchymal transition
- locally advanced
- drug delivery
- cell death
- stem cells
- electronic health record
- endoplasmic reticulum stress
- oxidative stress
- long non coding rna
- squamous cell carcinoma
- machine learning
- rectal cancer
- long noncoding rna
- radiation therapy