Increased IL-6 and Potential IL-6 trans-signalling in the airways after an allergen challenge.

Stephane EsnaultMehdi KhosraviElizabeth A KellyLin Ying LiuYury A BochkovMatthew C TattersallNizar N Jarjour

Published in: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology (2021)

After a bronchial allergen challenge, we found augmentation of the elements of IL-6 trans-signalling. Allergen-induced IL-6 trans-signalling activity can activate fibroblasts to produce chemokines that can further enhance inflammation and lung dysfunction.

Keyphrases

oxidative stress
allergic rhinitis
risk assessment
extracellular matrix
climate change
soft tissue