Longitudinal Changes in Skeletal Muscle Metabolism, Oxygen Uptake, and Myosteatosis During Cardiotoxic Treatment for Early-Stage Breast Cancer.
Amy A KirkhamEdith PituskinJohn R MackeyJustin G GrenierD Ian PatersonMark J HaykowskyRichard B ThompsonPublished in: The oncologist (2022)
Lower leg skeletal muscle blood flow and O2 extraction adapt to compensate for chemotherapy-related hemoglobin reduction for small muscle mass exercise but are insufficient to maintain large muscle mass exercise (pulmonary VO2peak, leg press strength). The excess O2 required to perform work, increased Pi:PCr ratio and myosteatosis together suggest suppressed fat oxidation during chemotherapy.
Keyphrases
- skeletal muscle
- blood flow
- early stage
- high intensity
- insulin resistance
- locally advanced
- physical activity
- adipose tissue
- resistance training
- pulmonary hypertension
- hydrogen peroxide
- radiation therapy
- nitric oxide
- squamous cell carcinoma
- type diabetes
- rectal cancer
- metabolic syndrome
- lymph node
- drug induced
- childhood cancer