Immunogenic cell death pathway polymorphisms for predicting oxaliplatin efficacy in metastatic colorectal cancer.
Hiroyuki AraiYi XiaoFotios LoupakisNatsuko KawanishiJingyuan WangFrancesca BattaglinShivani SoniWu ZhangChristoph MancaoBodour SalhiaShannon M MumenthalerDaniel J WeisenbergerGangning LiangChiara CremoliniAlfredo FalconeJoshua MillsteinHeinz-Josef LenzPublished in: Journal for immunotherapy of cancer (2021)
The predictive utility of ICD-related SNPs for the efficacy of oxaliplatin-based chemotherapy was demonstrated, warranting further validation studies to be translated into personalized treatment strategies using conventional cytotoxic agents in mCRC.