Sphingosine-1-phosphate protects against brain microvascular endothelial junctional protein disorganization and barrier dysfunction caused by alcohol.

Natascha G AlvesSarah Y YuanJerome W Breslin

Published in: Microcirculation (New York, N.Y. : 1994) (2018)

Alcohol impairs the barrier function and junctional organization of HBMEC monolayers. S1P enhanced barrier function and restored junctions in the presence of alcohol, and thus may be useful for restoring BBB function during alcohol intoxication.

Keyphrases

alcohol consumption
blood brain barrier
endothelial cells
multiple sclerosis
resting state
small molecule
functional connectivity
brain injury
protein protein