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Tinctorin, a new spiroterpenoid from the lichen Parmotrema tinctorum (Despr. ex Nyl.) Hale growing in Vietnam.

Phan-Si-Nguyen DongHoang-Vinh-Truong PhanJirapast SichaemHoai-Vu Nguyen-SiThanh-Nha TranLe-Thuy-Thuy-Trang HoangThi-Minh-Suong HuynhHuong Thi Thu LeDinh-Tri MaiTung-Lam NgoTien-Dung LeVan-Kieu Nguyen
Published in: Natural product research (2023)
A new spiroterpenoid, namely tinctorin ( 1 ), along with one known compound, norreticulatin ( 2 ), were isolated from the lichen Parmotrema tinctorum (Despr. ex Nyl.) Hale. Their structures were elucidated by extensive spectroscopic analyses and electronic circular dichroism (ECD) calculations. The absolute configuration of 2 was established for the first time. Compound 1 was evaluated for its inhibitory activity against α- glucosidase and found to be inactive.
Keyphrases
  • molecular docking
  • molecular dynamics simulations
  • density functional theory
  • molecular dynamics
  • high resolution