Obesity-related glomerulopathy in the presence of APOL1 risk alleles.
Ronald Valdez ImbertNang San Hti Lar SengMichael B StokesBelinda JimPublished in: BMJ case reports (2022)
Nephropathic apolipoprotein L1 (APOL1) risk alleles (G1/G2) have been associated with focal segmental glomerulosclerosis, HIV-associated nephropathy, Systemic lupus erythematosus (SLE)-associated collapsing glomerulopathy and other glomerulonephritides. These alleles confer protection from Trypanosoma brucei infections which are enriched in sub-Saharan African populations. We present a young woman with obesity, hypertension, subnephrotic range proteinuria who was found to have obesity-related glomerulopathy on kidney biopsy while harbouring two high-risk APOL1 alleles (G1/G2). Given the potential effects on lipid metabolism and their association with obesity, the presence of APOL1 risk alleles may impact cardiovascular health in addition to renal disease in these patients.
Keyphrases
- systemic lupus erythematosus
- insulin resistance
- metabolic syndrome
- weight loss
- high fat diet induced
- type diabetes
- weight gain
- disease activity
- newly diagnosed
- ejection fraction
- hepatitis c virus
- antiretroviral therapy
- prognostic factors
- hiv infected
- body mass index
- hiv positive
- skeletal muscle
- rheumatoid arthritis
- case report
- physical activity
- hiv aids
- climate change
- men who have sex with men
- genetic diversity