Kinomic profiling of glioblastoma cells reveals PLCG1 as a target in restricted glucose.

Kiera WalkerNathaniel H BoydJoshua C AndersonChristopher D WilleyAnita B Hjelmeland

Published in: Biomarker research (2018)

Together, our data demonstrate that kinase activity is altered in low glucose conditions and that kinomic profiling can assist with the identification of effective strategies to target GBM growth. Our data further suggest the importance of accurately modeling the tumor microenvironment to reproduce cancer cell signaling and develop drug screens for anti-cancer agents.

Keyphrases

electronic health record
induced apoptosis
single cell
big data
blood glucose
cell cycle arrest
high throughput
tyrosine kinase
type diabetes
oxidative stress
signaling pathway
metabolic syndrome
adverse drug
protein kinase
cell proliferation
deep learning
insulin resistance
pi k akt