Management of Pregnancy in Women of Advanced Maternal Age: Improving Outcomes for Mother and Baby.
Itamar GlickEla KadishMisgav RottenstreichPublished in: International journal of women's health (2021)
Pregnancy at advanced maternal age (age >35 years old) is considered a risk factor for adverse maternal and perinatal outcomes. Yet, pregnancies of advanced maternal age have become more prevalent over the last few decades. Possible maternal complications of pregnancy at age 35 or older include increased risk of spontaneous miscarriage, preterm labor, gestational diabetes mellitus, pre-eclampsia, stillbirth, chromosomal abnormalities, and cesarean delivery. Possible adverse fetal outcomes include infants small for gestational age and intrauterine growth restrictions, low Apgar score, admission to neonatal intensive care units, and an autism spectrum disorder. This paper aims to present an up-to-date review of the literature, summarizing the most current studies and implications for the management of pregnancy of advanced maternal age.
Keyphrases
- pregnancy outcomes
- birth weight
- gestational age
- preterm birth
- pregnant women
- autism spectrum disorder
- intensive care unit
- emergency department
- weight gain
- physical activity
- type diabetes
- intellectual disability
- gene expression
- insulin resistance
- attention deficit hyperactivity disorder
- extracorporeal membrane oxygenation