FLUAV RAM-IGIP: A modified live influenza virus vaccine that enhances humoral and mucosal responses against influenza.

C Joaquín CáceresL Claire GayAarti JainTeresa D MejíasMatias CardenasBrittany SeibertFlavio Cargnin FaccinBrianna CowanGinger GeigerAmy Vincent BakerSilvia CarnacciniD Huw DaviesDaniela S Rajao Daniel R Pérez

Published in: bioRxiv : the preprint server for biology (2024)

Current influenza vaccines offer suboptimal protection, leaving both humans and animals vulnerable. Our novel attenuated MLV vaccine, built by rearranging FLUAV genome segments and incorporating the IgA-inducing protein, shows promising results. This RAM-IGIP vaccine exhibits safe attenuation, robust immune responses, and complete protection against lethal viral challenge in mice. Its ability to stimulate broad-spectrum humoral and mucosal immunity against diverse FLUAV subtypes makes it a highly promising candidate for improved influenza vaccines.

Keyphrases

immune response
sars cov
dendritic cells
type diabetes
toll like receptor
genome wide
protein protein
high fat diet induced
amino acid
metabolic syndrome
skeletal muscle