Apoptosis repressor with caspase recruitment domain (ARC) promotes bone regeneration of bone marrow-derived mesenchymal stem cells by activating Fgf-2/PI3K/Akt signaling.

Longwei HuYang WangHongya Pan Kathreena Kadir Jin Wen Siyi Li Chenping Zhang

Published in: Stem cell research & therapy (2021)

The present study suggests that ARC is a powerful agent for promoting bone regeneration of BMSCs and provides a promising method for bone tissue engineering.

Keyphrases

bone regeneration
pi k akt
cell cycle arrest
signaling pathway
tissue engineering
cell death
bone marrow
induced apoptosis
cell proliferation
oxidative stress
endoplasmic reticulum stress
body composition