KRT17High/CXCL8+ tumor cells display both classical and basal features and regulate myeloid infiltration in the pancreatic cancer microenvironment.
Eileen S CarpenterPadma KadiyalaAhmed M ElhossinySamantha B KempJay LiNina G SteeleRemy NicolleZeribe Chike NwosuJulia FreemanHenry DaiDaniel PagliaWenting DuKatelyn L DonahueJacqueline MoralesPaola I Medina-CabreraMonica E BonillaLindsey HarrisStephanie TheValerie GunchickNicole PetersonKristee L BrownMichael MatteaCarlos E EspinozaJake McGueSarah M KabalaRachael K BaliiraNur M RenolletAyden G MooneyJianhua LiuSean BhallaJeremy P FaridaChristopher KoJorge D MachicadoRichard S KwonErik-Jan WamstekerAllison R SchulmanMichelle A AndersonRyan LawAnoop PrabhuPierre A CoulombeArvind RaoTimothy L FrankelFilip BednarJiaqi ShiVaibhav SahaiMarina Pasca Di MaglianoPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2023)
Through single cell analysis of PDAC samples we identified KRT17High/CXCL8+ cancer cells as an intermediary subtype, marked by a unique cytokine profile and capable of influencing myeloid cells in the tumor microenvironment and systemically. The abundance of this cell population should be considered for patient stratification in precision immunotherapy.