Red Orange and Lemon Extract Ameliorates the Renal Oxidative Stress and Inflammation Induced by Ochratoxin A through the Modulation of Nrf2.

Consiglia Longobardi Sara Damiano Simona Fabroni Serena MontagnaroValeria RussoEmanuela VaccaroAntonio Giordano Salvatore Florio Roberto Ciarcia

Published in: Toxins (2024)

Our findings showed a significant increase in oxidative and inflammatory parameters after OTA exposure, while the OTA + RLE co-treatment counteracted both the inflammatory and OS damage through the modulation of the Nrf2 pathway.

Keyphrases

oxidative stress
diabetic rats
dna damage
ischemia reperfusion injury
induced apoptosis
mouse model
heat shock
combination therapy