Right ventricular outflow tract obstruction associated with neointimal tissue accumulation and distortion of the Harmony TPV25 stent frame: Potential mechanisms and treatment.

Zachary L SteinbergAllison K CabalkaDavid T BalzerJeremy D Asnes Brian H MorrayMatthew J GillespieDoff B McElhinney

Published in: Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions (2023)

The occurrence of short-term Harmony TPV25 dysfunction in multiple patients with a similar appearance of frame distortion and tissue accumulation within the inflow and valve housing portions of the device suggests that this may be an important failure mechanism for this valve. Potential causes of the observed findings are discussed. It is possible to treat this mechanism of TPV25 dysfunction with valve-in-valve implant using balloon expandable transcatheter valves.

Keyphrases

aortic valve
mitral valve
aortic stenosis
transcatheter aortic valve replacement
aortic valve replacement
transcatheter aortic valve implantation
oxidative stress
risk assessment
human health
left ventricular
heart failure
mental health
soft tissue