Synthesis, structure, and antitumor activity of 2,9-disubstituted perhydro 2,3a,7b,9,10a,14b-hexaazadibenzotetracenes.
Elena B RakhimovaVictor Yu KirsanovElena V Tret'yakovaLeonard M KhalilovAskhat G IbragimovLilya U DzhemilevaVladimir A D'yakonovUsein M DzhemilevPublished in: RSC advances (2020)
Catalytic methods for the synthesis of previously unknown 2,9-disubstituted 3b R *,7a R *,10b R *,14a R *- cis -14c,14d-perhydro-2,3a,7b,9,10a,14b-hexaazadibenzotetracenes have been developed. The structures were established by 1D ( 1 H, 13 C) and 2D (COSY, HSQC, HMBC) NMR spectroscopy, MALDI TOF/TOF mass spectrometry, and X-ray diffraction analysis. Primary screening of the synthesized perhydro hexaazadibenzotetracenes for antitumor activity was carried out.