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Total Synthesis of (+)-Jatrophalactam.

Jianhong GaoDongyu SunKuan YuHujun XieHanfeng Ding
Published in: Organic letters (2019)
The first asymmetric total synthesis of (+)-jatrophalactam was reported, which unambiguously determined the absolute configuration of the titled natural product. The key features entail a conformationally controlled cyclopropanation, a Meldrum's acid adduct-engaged macrolactam formation, and a Pd(II)-mediated oxidative cyclization.
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