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Diagnostic utility of 18F-Fluorodeoxyglucose positron emission tomography (FDG-PET) in asymptomatic subjects at increased risk for Alzheimer's disease.

Alexander DrzezgaDaniele AltomareCristina FestariJavier ArbizuStefania OriniKarl HerholzPeter NestorFederica AgostaFemke BouwmanFlavio NobiliZuzana WalkerGiovanni Battista FrisoniMarina Boccardinull null
Published in: European journal of nuclear medicine and molecular imaging (2018)
Currently, there is limited evidence on which to base recommendations regarding the clinical routine use of FDG-PET to detect diagnostically meaningful early signs of neurodegeneration in asymptomatic subjects with ADAD, with APOE ε4-positive genotype, or with cerebral amyloid pathology, and in subjects with SCD. Future prospective studies are warranted and in part already ongoing, aiming to assess the added value of FDG-PET in this context beyond research applications.
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