mRNA expression profile of bronchoalveolar lavage fluid cells from patients with idiopathic pulmonary fibrosis and sarcoidosis.

Magdalena Paplińska-Goryca Krzysztof Goryca Paulina Misiukiewicz-Stępień Patrycja Nejman-Gryz Małgorzata Proboszcz Katarzyna Gorska Marta Maskey-Warzęchowska Rafał Krenke

Published in: European journal of clinical investigation (2019)

Analysis of BALf from sarcoidosis and IPF showed highly different mRNA profile of cells. The most important biological processes observed at the molecular level in BALf cells were associated with ribosome biogenesis and proteasome apparatus in sarcoidosis and neutrophilic dysfunction in IPF.

Keyphrases

idiopathic pulmonary fibrosis
induced apoptosis
cell cycle arrest
interstitial lung disease
oxidative stress
endoplasmic reticulum stress
signaling pathway
cell proliferation