The Asialoglycoprotein Receptor Minor Subunit Gene Contributes to Pharmacokinetics of Factor VIII Concentrates in Hemophilia A.

Barbara LunghiMassimo MorfiniNicola MartinelliDario BalestraSilvia LinariSabrina FrusconiAlessio BranchiniChristian F CervelleraGiovanna MarchettiGiancarlo CastamanFrancesco Bernardi

Published in: Thrombosis and haemostasis (2021)

Infused FVIII distribution was modulated by frequent ASGR2 genotypes, independently from and together with ABO and VWF antigen levels, which has potential implications for genetically tailored substitutive treatment in HA.

Keyphrases

copy number
genome wide
combination therapy
transcription factor
replacement therapy
genome wide analysis