Spliceosomal profiling identifies EIF4A3 as a novel oncogene in hepatocellular carcinoma acting through the modulation of FGFR4 splicing.
Juan L López-CánovasNatalia Hermán-SánchezMaria Trinidad Moreno-MontillaMercedes Del Rio-MorenoEmilia Alors-PerezMarina E Sánchez-FriasVíctor AmadoRubén CiriaJavier BriceñoManuel de la MataJusto P CastañoManuel Rodriguez-PerálvarezRaúl M LuqueManuel D GahetePublished in: Clinical and translational medicine (2022)
Splicing machinery is strongly dysregulated in HCC, providing a source of new diagnostic, prognostic and therapeutic options in HCC. EIF4A3 is consistently elevated in HCC patients and associated with tumour aggressiveness and mortality, through the modulation of FGFR4 splicing.