Monitoring Therapeutic Response to Anti-Fibroblast Activation Protein (FAP) CAR T Cells using [18F]AlF-FAPI-74.

Iris K Lee Estela Noguera-Ortega Zebin Xiao Leslie Todd John Scholler Decheng Song Maria Liousia Katheryn Lohith Kexiang Xu Kimberly J Edwards Michael D Farwell Carl H June Steven M Albelda Ellen Puré Mark A Sellmyer

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2022)

This non-invasive imaging approach to interrogate the tumor microenvironment represents an innovative pairing of a diagnostic PET probe with solid tumor CAR T cell therapy and has the potential to serve as a predictive and pharmacodynamic response biomarker for FAP as well as other stromal cell-targeted therapies.

Keyphrases

cell therapy
stem cells
mesenchymal stem cells
high resolution
bone marrow
computed tomography
pet ct
positron emission tomography
quantum dots
living cells
protein protein
binding protein
mass spectrometry
fluorescence imaging
single molecule