Novel Role of 5-Methyl-(6S)-Tetrahydrofolate in Mediating Endothelial Cell Tetrahydrobiopterin in Pregnancy and Implications for Gestational Hypertension.

Yasmin DickinsonRuth BoehniRima ObeidJean-Pierre KnappRudolf MoserAdam J LewandowskiGillian Douglas Paul LeesonKeith M ChannonSurawee Chuaiphichai

Published in: Hypertension (Dallas, Tex. : 1979) (2024)

Collectively, these studies identify a critical role for 5-MTHF in endothelial cell function in pregnancy, related to endothelial cell BH4 availability and NO synthase activity. Thus, 5-MTHF represents a novel therapeutic agent that may potentially improve endothelial function in hypertensive disorders of pregnancy by targeting endothelial cell BH4.

Keyphrases

endothelial cells
pregnancy outcomes
preterm birth
blood pressure
high glucose
pregnant women
vascular endothelial growth factor
birth weight