Stoichiometrically Governed Curcumin Solid Dispersion and Its Cytotoxic Evaluation on Colorectal Adenocarcinoma Cells.

Jamal Moideen Muthu MohamedAli Musfer AlqahtaniFazil AhmadV KrishnarajuK Kalpana

Published in: Drug design, development and therapy (2020)

This study confirmed that the ideal stoichiometric ratio of CMN with carrier to enhance its solubility was 1:1. This molecular complex of PXM-407 was found to be more effective against colorectal cancer (CRC) than pure CMN.

Keyphrases

induced apoptosis
squamous cell carcinoma
endoplasmic reticulum stress
oxidative stress
single molecule
signaling pathway