Placental CpG methylation of infants born extremely preterm predicts cognitive impairment later in life.

Sloane K TilleyElizabeth M MartinLisa SmeesterRobert M JosephKarl C K KubanTim C HeerenOlaf U DammannT Michael O'SheaRebecca C Fry

Published in: PloS one (2018)

A hypermethylation signature is present in DNA from placentas in infants with spontaneous EPTB. CpG methylation levels of critical neurodevelopment genes in the placenta predicted later life cognitive function, supporting the developmental origins of health and disease hypothesis (DOHaD).

Keyphrases

dna methylation
genome wide
cognitive impairment
low birth weight
gestational age
healthcare
public health
gene expression
mental health
preterm birth
cell free
preterm infants
circulating tumor
health information
bioinformatics analysis
nucleic acid