Effects of acupuncture on microglial polarization and the TLR4/TRIF/MyD88 pathway in a rat model of traumatic brain injury.
Lu-Xi CaoShu-Jun LinSi-Si ZhaoShi-Qi WangHai ZengWen-An ChenZhuo-Wen LinJia-Xu ChenMing-Min ZhuYi-Min ZhangPublished in: Acupuncture in medicine : journal of the British Medical Acupuncture Society (2022)
The results of this study demonstrate that one of the mechanisms through which acupuncture mitigates neuroinflammation and promotes nerve repair in TBI rats may be inhibition of M1 phenotypic polarization and promotion of M2 phenotypic polarization through inhibition of the TLR4/TRIF/MyD88 signaling pathway.
Keyphrases
- traumatic brain injury
- toll like receptor
- inflammatory response
- signaling pathway
- lipopolysaccharide induced
- lps induced
- nuclear factor
- immune response
- severe traumatic brain injury
- pi k akt
- epithelial mesenchymal transition
- neuropathic pain
- radiation therapy
- brain injury
- spinal cord injury
- cognitive impairment
- cell proliferation
- blood brain barrier
- peripheral nerve
- subarachnoid hemorrhage
- oxidative stress
- endoplasmic reticulum stress
- cerebral ischemia