Quantifying substantial carcinogenesis of genetic and environmental factors from measurement error in the number of stem cell divisions.

Xinhui LiuJifeng YangHongkai LiQing WangYuanyuan YuXiaoru SunShucheng SiLei HouLu LiuFan YangRan YanYifan YuZhentao FuZilong LuDejin LiHao XueXiaolei GuoFuzhong XueXiaokang Ji

Published in: BMC cancer (2022)

This work provides additional evidence that genetic and environmental factors play leading roles in cancer development. Therefore, the identification of modifiable environmental and hereditary risk factors for each cancer is highly recommended, and primary prevention in early life-course should be the major focus of cancer prevention.

Keyphrases

papillary thyroid
stem cells
early life
squamous cell
squamous cell carcinoma
dna methylation
copy number
mesenchymal stem cells
climate change
life cycle