Polo-like Kinase 1 as a potential therapeutic target in Diffuse Intrinsic Pontine Glioma.

Vladimir AmaniEric W PrinceIrina AlimovaIlango BalakrishnanDiane BirksAndrew M DonsonPeter HarrisJean M Mulcahy LevyMichael HandlerNicholas K ForemanSujatha VenkataramanRajeev Vibhakar

Published in: BMC cancer (2016)

These findings suggest that targeting PLK1 with small-molecule inhibitors, in combination with radiation therapy, will hold a novel strategy in the treatment of DIPG that warrants further investigation.

Keyphrases

small molecule
radiation therapy
low grade
cancer therapy
tyrosine kinase
protein kinase
radiation induced
climate change