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Physiological cyclic hydrostatic pressure induces osteogenic lineage commitment of human bone marrow stem cells: a systematic study.

Elena StavenschiMichele A CorriganGillian P JohnsonMathieu RiffaultDavid A Hoey
Published in: Stem cell research & therapy (2018)
Overall, these findings demonstrate an important role for cyclic hydrostatic pressure in hBMSCs and bone mechanobiology, which should be considered when studying pressure-driven fluid shear effects in hBMSCs mechanobiology. Moreover, these findings may have clinical implication in terms of bioreactor-based bone tissue engineering strategies.
Keyphrases
  • bone marrow
  • tissue engineering
  • stem cells
  • mesenchymal stem cells
  • bone mineral density
  • endothelial cells
  • soft tissue
  • bone loss
  • bone regeneration
  • cell fate
  • body composition
  • cell therapy