Age is in the Eye of the Beholder: Distinguishing Molecular Signatures in Early-onset Pancreatic Adenocarcinomas.

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2020)

Pancreatic ductal adenocarcinoma (PDAC) is more prevalent in older patients, but early-onset cases (<55 years) may be a distinct genetic subpopulation. Differential expression of CDKN2A and transcription factor FOXC2 were found in early-onset cases. This finding opens the door to investigating additional features that distinguish PDAC tumors in this age group.See related article by Tsang et al., p. 246.

Keyphrases

early onset
late onset
transcription factor
gene expression
dna binding
dna methylation