A new integrative analysis of histopathology and single cell RNA-seq reveals the CCL5 mediated T and NK cell interaction with vascular cells in idiopathic pulmonary arterial hypertension.
Xincheng LiShuangshuang MaQi WangYishan LiXiaofan JiJixiang LiuJing MaYongbing WangZhu ZhangHong ZhangHong ChenLinfeng XiYunxia ZhangWanmu XieLu SunZhihui FuPeiran YangChen WangZhen-Guo ZhaiPublished in: Journal of translational medicine (2024)
Our study identified a new inflammatory pathway in IPAH, where T and NK cells drove heightened inflammation predominantly via the upregulation of CCL5, providing groundwork for the development of targeted therapeutics.
Keyphrases
- nk cells
- rna seq
- single cell
- pulmonary arterial hypertension
- oxidative stress
- pulmonary artery
- induced apoptosis
- pulmonary hypertension
- liver injury
- liver fibrosis
- high throughput
- cell cycle arrest
- cell proliferation
- cancer therapy
- endoplasmic reticulum stress
- cell death
- drug induced
- african american
- drug delivery
- long non coding rna
- network analysis