Re-evaluation of hypoplastic left heart syndrome from a developmental and morphological perspective.

A CruceanA AlqahtaniD J BarronW J BrawnR V RichardsonJ O'SullivanR H AndersonD J HendersonBill Chaudhry

Published in: Orphanet journal of rare diseases (2017)

Only the slit-like ventricle grouping was found to map to the current nomenclature: the combination of mitral atresia with aortic atresia. It appears that slit-like and miniature ventricles also form discrete sub-groups. Thus, reclassification of HLHS into subgroups based on ventricular phenotype, might be useful in genetic and developmental studies in investigating the aetiology of this severe malformation syndrome.

Keyphrases

left ventricular
mitral valve
heart failure
pulmonary artery
case report
pulmonary hypertension
aortic valve
left atrial
genome wide
early onset
atrial fibrillation
gene expression
coronary artery disease
pulmonary arterial hypertension
case control
drug induced