Characterization of brain development with neuroimaging in a female mouse model of chemotherapy treatment of acute lymphoblastic leukemia.

Kellen Gandy Timothy R KoscikTyler AlexanderJeffrey D SteinbergKevin R KrullEllen van der Plas

Published in: Translational pediatrics (2024)

The results demonstrate feasibility of modeling pediatric ALL treatment in a preclinical model and highlight the potential of using preclinical neuroimaging models to gain insight into brain development throughout survivorship.

Keyphrases

acute lymphoblastic leukemia
mouse model
white matter
resting state
stem cells
multiple sclerosis
functional connectivity
young adults
risk assessment
acute myeloid leukemia
allogeneic hematopoietic stem cell transplantation
replacement therapy