TP53/mTORC1-mediated bidirectional regulation of PD-L1 modulates immune evasion in hepatocellular carcinoma.

Jiongjie YuSunbin LingJiachen HongLincheng ZhangWei ZhouLu YinShengjun XuQingyang QueYongfeng WuQifan ZhanJiaqi BaoNan XuYuchen LiuKangchen ChenXuyong WeiZhikun LiuTingting FengLin ZhouHaiyang XieShuai WangJimin LiuShusen ZhengXiao Xu

Published in: Journal for immunotherapy of cancer (2023)

We revealed the bidirectional regulatory mechanism of PD-L1 mediated by TP53/mTORC1 in HCC. The combination of mTOR inhibitor and anti-PD-L1 antibody could be a novel precise immunotherapy scheme for TP53 wild-type HCC.

Keyphrases

wild type
transcription factor
cell proliferation